The University of Iowa Role in the Science Behind Psilocybin for Psychiatric Treatment

On April 9, 2024, the University of Iowa educational podcast, Rounding@Iowa presented a discussion about the study of the use of psilocybin in the treatment of psychiatric and addiction disorders. You can access the podcast below. The title is “Psilocybin Benefits and Risks.” The format involves an interview by Dr. Gerard Clancy, MD, Senior Associate Dean for External Affairs, Professor of Psychiatry and Emergency Medicine with distinguished University of Iowa faculty and clinician researchers.

In this presentation, the guest interviewees are Dr. Michael Flaum, MD, Professor Emeritus in Psychiatry, University of Iowa Carver College of Medicine, and Dr. Peggy Nopoulos, MD, Chair and Department Executive Officer for the University of Iowa Department of Psychiatry, Professor of Neurology, Pediatrics, and Psychiatry, University of Iowa Carver College of Medicine.

All three of these highly respected and accomplished faculty taught me when I was a trainee in the psychiatry department and afterward were esteemed colleagues.

87: New Treatment Options for Menopause Rounding@IOWA

Join Dr. Clancy and his guests, Drs. Evelyn Ross-Shapiro, Sarah Shaffer, and Emily Walsh, as they discuss the complex set of symptoms and treatment options for those with significant symptoms from menopause.  CME Credit Available:  https://uiowa.cloud-cme.com/course/courseoverview?P=0&EID=81895  Host: Gerard Clancy, MD Senior Associate Dean for External Affairs Professor of Psychiatry and Emergency Medicine University of Iowa Carver College of Medicine Guests: Evelyn Ross-Shapiro, MD, MPH Clinical Assistant Professor of Internal Medicine Clinic Director, LGBTQ Clinic University of Iowa Carver College of Medicine Sarah Shaffer, DO Clinical Associate Professor of Obstetrics and Gynecology Vice Chair for Education, Department of Obstetrics and Gynecology University of Iowa Carver College of Medicine Emily Walsh, PharmD, BCACP Clinical Pharmacy Specialist Iowa Health Care Financial Disclosures:  Dr. Gerard Clancy, his guests, and Rounding@IOWA planning committee members have disclosed no relevant financial relationships. Nurse: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this activity for a maximum of 1.00 ANCC contact hour. Pharmacist and Pharmacy Tech: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this knowledge-based activity for a maximum of 1.00 ACPE contact hours. Credit will be uploaded to the NABP CPE Monitor within 60 days after the activity completion. Pharmacists must provide their NABP ID and DOB (MMDD) to receive credit. JA0000310-0000-26-029-H01 Physician: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this enduring material for a maximum of 1.00 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Other Health Care Providers: A certificate of completion will be available after successful completion of the course. (It is the responsibility of licensees to determine if this continuing education activity meets the requirements of their professional licensure board.) References/Resources:   
  1. 87: New Treatment Options for Menopause
  2. 86: Cancer Rates in Iowa
  3. 85: Solutions for Rural Health Workforce Shortages
  4. 84: When to Suspect Atypical Recreational Substances
  5. 83: Hidradenitis Suppurativa

The link icon adjacent to the title of the podcast takes you to the podcast website. The link to the article in Iowa Magazine about the psilocybin research at University of Iowa Health Care tells you more about Dr. Peggy Nopoulos and her role as principal investigator in the study.

There is also a link to the National Library of Medicine Clinical Trials web site where you can find out more details about the study design. You’ll notice a banner message which says: “The U.S. government does not review or approve the safety and science of all studies listed on the website” along with another link to a disclaimer with more details.

KCCK Big Mo News and More

Well, ever since last fall, the Iowa jazz and blues radio station KCCK has been available only on channel 88.3 FM on our radio dial. Channel 106.9 has been out for months. We just found out that 106.9 is now working again and has been for over 3 weeks. It has been a translator channel that broadcasts in addition to 88.3 FM out of Cedar Rapids so that people in Iowa City can have better reception.

The story about why KCCK 106.9 has been out is complicated and traces back to when the Daily Iowan reported in early October of 2023 that because the Iowa City campus of Kirkwood Community College closed, the antenna for KCCK in the area was shut down and other arrangements had to be made for KCCK radio reception in Iowa City.

We never really lost KCCK reception, except on 106.9. It always came through just fine on 88.3. But just a couple nights ago, I heard John Heim aka Big Mo who broadcasts the Big Mo Blues Show on Friday nights starting at 6:00 PM say, as usual, that KCCK is on 88.3 in Cedar Rapids and in Iowa City by translator channel 106.9. He has been saying that for months but nothing came through but static mostly.

And now KCCK 106.9 is back, just like that.

The other news from KCCK is that Big Mo has a Pod cast show now. It just started in recent weeks also. One of them reminds me of what turns out to be a comedy bit he does about May Ree’s hand-battered catfish. He always says she is one of the sponsors for his show. I’ve had my doubts about it but enjoy it anyway. I was evidently one of the many who contacted him asking whether or not the hand-battered catfish story is real. He just advised me to “keep listening.”

It’s not real, but it’s funny. It’s one of a few “Sponsors de faux” comedy bits he has done for a long time. I remember wondering about May Ree and her hand-battered catfish at least a couple of years ago. He has a couple of others which I’ve never heard about: Shorty’s Adult Diapers and Big Furry Shaving Products. I’ve blogged about May Ree a few times. Just search “hand battered catfish.”

Anyway, I thought I’d just pass this along. You can have a lot of fun listening to KCCK radio out of Cedar Rapids and Iowa City, Iowa. I guess now only newcomers will ask whether the May Ree’s Hand-Battered Catfish story is real or not. KCCK of Iowa welcomes new listeners, so…keep listening.

This is National Scrabble Day

I almost forgot that April 13 is National Scrabble Day. I don’t think I’ve ever blogged about it before, so I’ll inflict some thoughts on you now about it and add some others about International Cribbage Day, which is on February 10 annually—and which I evidently tend to forget every year.

The big news about Scrabble is that it’s changing in a major way, at least in Europe. I guess some people think the game is too difficult and they want to make it less “intimidating.” That’s what Mattel in Europe says, anyway. Others accuse the company of “dumbing it down.” I guess a certain generation of players want the game to be less competitive and more cooperative.

The thing about Scrabble Together is that it’s available only in Europe—for now. I just found out that Mattel is based in California and owns the rights to the game around most of the world. However, Hasbro licenses the game in the U.S. and has no plan to offer Scrabble Together in America.

We play Scrabble rarely—I’m not a very good player so I tend to avoid it. Sena has a couple of computer versions on CD, The Hasbro version of which is getting to be about eBay age. I think I bought it in 1999 (or was it 1998?) at Best Buy, back in the day when you could buy stuff in the actual stores. Even though the shelves looked pretty bare the last time I was there, web articles indicate it’s not going out of business, just evolving into online retailing.

Sena plays Maven (an interactive character that morphs, makes noises, and makes fun of or cheers your plays) on the Hasbro CD Scrabble version. She plays the Advanced Level and says she loses most of the time. Maven is very competitive. Funny thing, this doesn’t discourage Sena from playing. I tried to play Maven yesterday and got slaughtered. Maven thought it was pretty funny.

This change to Scrabble Together reminds me of a big story about a guy named Nigel Richards who won the French World Scrabble Championship Tournament in 2015—and he doesn’t speak a word of French. He memorized the French Dictionary. He concentrates on maximizing his scores without focusing on the actual words. It’s really more about the numbers than the vocabulary. Nigel Richards is definitely competitive and probably would not be interested in Scrabble Together.

Scrabble Together could attract more young people to an old game, which is more than you might say about cribbage. Just to be clear, cribbage is a competitive game and always has been. Every once in a while, you’ll see interesting descriptions about this two-hander card game which uses a board and can teach you a thing or two about math, strategy, logic, and building friendships.

People often observe that typical cribbage players tend to be older. It’s common to see there are fewer players under the age of 50. Many fans of cribbage try to attract younger players to the game by extolling its virtues and assuring younger novices they’ll be treated kindly. You can see that on the American Cribbage Congress (ACC) website page entitled “Cribbage Club Code of Congeniality.” Cribbage, while a competitive game, can be supportive as well. It’s not impossible.

Try not to let an experienced cribbage enthusiast persuade you to play for money.

The Wendy’s Orange Dreamsicle Frosty Is In Your Dreams

Well, we stopped by the Wendy’s drive up a couple of days ago and tried to order that new Orange Dreamsicle (sometimes called the Creamsicle) Frosty. But they were out of it, mainly because they didn’t order enough of it. I guess it’s a hot-cold item (Har!). They encouraged us to return the next day, which we did.

They had plenty of Orange Frosty. They said it was just like those orange Push-Up Pops you got when you were a kid (what gives? I never got one). Sena said the Push-Ups tasted like orange sherbet, so she was looking forward to it.

OK, if we’d been blindfolded and didn’t know about it in the first place—we wouldn’t have been able to tell there was anything orange about it but the color.

It was a nice enough color, but it tasted so much like vanilla we wondered why they were calling it orange. We thought the same thing about the strawberry and peppermint Frosty’s. The only one that was a hit for us was the Pumpkin Spice flavor—even though some foodies said the main ingredients were milk and soy. Some said it reminded them of eggnog. I got nothing against eggnog.

So, what was in the Orange Push-Ups? I looked this up on line and they were made of cream and orange juice concentrate.

What exactly is in the Orange Dreamsicle Frosty? The dessert is aptly named, because you’re dreaming if you think you’re getting any orange in it.

It’s got milk, sugar, corn syrup, cream, and non-fat milk, plus thickeners and additives for color. There is no orange or even tangerine in it.

What do you want to bet that’s what’s in all the other flavors? When the new flavors come out, Wendy’s says they can’t give you vanilla. Funny, because that’s what most of them taste like. I’m pretty sure it’s because they use the vanilla as a base to make the new flavors.

That’s OK with me because vanilla is my favorite anyway. And chocolate is a close second. Anytime Wendy’s has a new Frosty, we’re up for it!

Our Solar Eclipse Day: A Happening on Terry Trueblood Trail

Yesterday, we went out to Terry Trueblood Recreation Area to see the solar eclipse. It was a gorgeous day for it, although a bit chilly. When we got there about 11:30 AM, the parking lot was pretty empty and only a few people were there. We even ran into a few on the trail who didn’t know about the eclipse at all.

However, as the day went on, more visitors showed up, although by no means a crushing crowd. Sena and I were testing out our pinhole and cereal box viewers, and I practiced using the solar filter with my smartphone. While we were doing that, a woman approached us and we struck up a great conversation about the eclipse, which she was looking forward to as well.

As the time approached for the big event, others took up positions around the park. It didn’t take long for us to share stories with others. A woman shared her pinhole viewer with us. She also shared her eclipse glasses (Sena did as well) with another couple who had a NASA live feed on their large screen smartphone. They in turn shared the NASA live feed with us. The irony was the couple didn’t have eclipse glasses and couldn’t safely look up at the partial eclipse right where we were in Iowa City.

And that’s how we all got to share our experience of 4 eclipses, 3 of them total eclipses (albeit vicariously by the NASA live feed by smartphone) with Carbondale, Illinois as well as Arkansas and Texas. The videos were mesmerizing.

As the eclipse progressed, we noticed it got colder and darker. The birds stopped singing. On the NASA live feed, we heard a reporter excitedly remark that the bats were flying out of the caves because they thought it was nightfall. The Terry Trueblood Park lights turned on it got so dim; then they came back on as the eclipse reversed.

The eclipse itself was spectacular. Even more fascinating was how it brought some of us together with others to share it. It reminded me of an old term “the happening.” It was coined in the 1950s and, although I think it originally referred to artistic events, you could apply it to a lot of big and cool events—like eclipses. It was a happening.

Off to See the Eclipse!

We’ll be off to try to see the eclipse today, because the weather report yesterday (and this morning!) said it would be sunny and warm.

For the occasion, I made a cereal box eclipse viewer just for fun. We’ll see if it works. I sacrificed a box of Raisin Bran for it. Sena wondered where her cereal box viewer was. We had only one box of cereal in the pantry.

And we’ve got some eclipse glasses. Good luck out there!

Partial Social Eclipse Viewing on the Pentacrest April 8, 2024!

The University of Iowa Dept of Physics and Astronomy and the Sciences Library invites the public to view the partial solar eclipse on April 8, 2024 between 12:30 PM-3:00 PM at the Pentacrest and the Sciences Library courtyard. Solar eclipse glasses free while they last.

Solar Eclipse Around the Corner So We May Need to Protect the Cicadas!

The solar eclipse is just around the corner! We’re hoping for decent weather. We’re also hoping that everyone views the event with safety in mind.

University of Iowa Health Care ophthalmologist Dr. Ian Han has great tips on how to observe the solar eclipse on April 8, 2024. He pointed out that eclipse glasses that pass muster for safe viewing of what will be a partial eclipse in Iowa are typically on a list of approved eyewear and often have an ISO (that stands for International Organization for Standardization) number stamped on them. Our glasses have the right stuff!

However, animals sometimes get confused by solar eclipses, including cicadas (see my other post about cicada weirdness posted today). Cicadas might stop singing or maybe their gonads drop off a little sooner than usual, I don’t know exactly. But the zombie cicada gonad apocalypse timing probably makes that a non-issue. I did say “probably.” But how could we protect them if necessary?

There might be a scientific way to custom fit the cicadas with solar eclipse glasses using groundbreaking technology first used in the 1989 documentary film, “Honey, I Shrunk the Kids,” which I have not personally watched but which could be featured on Svengoolie. We’d have to scale up production for possibly trillions of bugs. And I guess we can’t protect their gonads.

But we can all protect our eyes.

Update: I found a very good web site which tells you how to check if your solar eclipse glasses are genuine and protective. In addition to the information above, you can test the eclipse glasses indoors by putting them on. You shouldn’t be able to see anything but the brightest light bulbs and those just barely. You can test them outside as well. On a sunny day, look around at any reflective surface. You shouldn’t be able to see much at all. I tested ours and they passed with flying colors.

Cicada Zombieland

I’m sure you’ve heard the zombie cicada horror movie-like story in the news which sounds like it would make a great episode for the Svengoolie TV show. “Attack of the hallucinating zombie cicadas without gonads” would make a good title. One possible torrid scene suggestion would open in the “living” room (although zombies are not really alive), female (Alice) and male (Fred) cicadas seated on the sofa, lava lamp on the coffee table:

Fred: Alice baby, what’s your sign?

Alice: Your gonads are off, hon.

Fred: Oops. Did I leave them at the racquetball court?

Alice: Hmmm. Have you had your…shots?

Fred: What do you mean?

Alice: You’re not carrying any sexually transmitted diseases, are you?

Fred: I hardly see how that’s possible, since my gonads fell off somewhere. Have another drink of my psychedelic fungus urine, which I am able to shoot out stronger and faster than an elephant!

Alice: Not erotic enough in my book. I’m leaving, Fred.

Fred: Wait a minute, Alice. I’m sure my gonads are around here somewhere; let me check between the sofa cushions!

Cicadas are those bugs which make extremely loud buzzing noises every 13 or every 17 years or whatever, when they dig their way out of the ground to climb trees, molt, and find mates. Sex is the main event for them and possibly trillions of them will be looking to get lucky in the biggest invasion in over 200 years, at least in the southeastern United States.

On the other hand, there is something seriously wrong with some of them. A parasitic fungus with an LSD-like or amphetamine-like substance takes over the males and their sexual equipment just falls right off, replaced by fungus gobs which stick on to other males or females, infecting them and turning them into sex-crazed zombies which kill each other off faster than Woody Harrelson can slaughter the walking dead in Zombieland (a movie I never saw).

This reminds me of a couple of X-Files episodes, as I’m sure it reminds you. One of them is Firewalker in which a silicon-based fungus infects a crew of scientists and kills them off by making them zombie-like spreaders of it, complete with a long, strangely phallic-like sprout which explodes out of their necks, after the victims gradually become psychotic.

The other X-Files episode is Field Trip in which Mulder and Scully get trapped underground covered in a giant gooey fungus which makes them hallucinate their brains out. At the same time, it’s digesting them. Yum.

I don’t think the X-Files producers got the idea for the episodes from the cicada zombies.