Category: current events

Will Iowans Get the Whole Enchilada with The Upcoming Total Solar Eclipse?

So, are Iowans going to get “the whole enchilada” when it comes to seeing the total solar eclipse on April 8, 2024? No, but we’ll see a partial eclipse. The T-shirt Sena got for me says “Total Eclipse” on it—but it also has extraterrestrials on it, which I really like.

The paths of these total eclipses are narrow. The path of the Total Solar Eclipse on August 21, 2017 would not have been visible in the totality phase for Iowans either. So, no whole enchilada then either.

In fact, I don’t remember the 2017 solar eclipse at all. Sena watched it on TV when CNN televised a special program about it. She noticed that it got dark, probably in the early afternoon. I don’t know what I was doing, but I was no doubt running around the hospital responding to psychiatry consultation requests. I probably wouldn’t have noticed a gigantic enchilada stalking the earth.

In fact, to see a total eclipse back then and next month, we’d have to drive to Carbondale, Illinois. That’s at least a 6-hour drive and probably longer since a lot of people would be on the road with the same goal. There are already warnings from some officials about traffic jams, cell phone problems, and other disasters which can happen during the mad rush to see the whole enchilada.

Which brings me to the question: do you know the origin of the phrase “the whole enchilada”?

I guess the history of the expression is a little dark, in a manner of speaking. Some people don’t define it and bail by comparing it to other similar phrases like “the whole nine yards” or whatever. On the other hand, there are variations on another story of the origin that date back to the Watergate tapes scandal in the era of President Nixon’s administration in the 1970s. Supposedly, John Ehrlichmann called Attorney John N. Mitchell “the big enchilada.”

In general, it means the whole thing, the entirety, everything. So, if we want to see the whole enchilada as far as the total solar eclipse on April 8, 2024, we’d have to drive 6 hours to either Carbondale, Illinois or Poplar Bluff, Missouri. We’ll pass on that.

However, Sena did make the whole enchilada last night for dinner.

Getting Ready for the Solar Eclipse!

Sena has placed the order for our eclipse glasses and eclipse T-shirts. They should get here in plenty of time for the solar eclipse on April 8, 2024. And if the weather is really crappy that day—we have 30 days to return them.

There is an interesting history of eclipses on the NASA website. It mentions how Einstein hypothesized that gravity warped space and time, distorting the universe. The sun is big enough that its gravity could bend light. In fact, during the eclipse on May 29, 1919, scientists noted that some stars were in the wrong place, proving Einstein’s theory.

And now for some eclipse jokes:

What do you call it when you fall in love on April 8, 2024? A total eclipse of the heart.

What will the moon bring to the beach on April 8, 2024? Sunblock.

Jupiter to the moon on April 8, 2024: Do you remember the sun?

Moon: No, I blocked it out.

Sena: How do you organize a solar eclipse party?

Jim: I don’t know. How?

Sena: You planet!

An interesting Iowa history story is about the solar eclipse of 1869. Several small markers were placed in various locations to mark the event. Many were lost. They were plowed out or covered up. The author mentions the upcoming 2024 solar eclipse and wonders if anyone will leave markers to remember it.

I think what some may leave behind are tattered eclipse glasses and cheeseburger wrappers. But we’ll have our memories to pass on in stories, pictures, and dad jokes—a living monument.

Solar Eclipse in April!

We just found out there’s going to be a total solar eclipse on April 8, 2024. We hope to get some solar eclipse glasses before then if they don’t run out of stock everywhere. They’re selling fast.

We’ve seen a couple of lunar eclipses and those were fun. The most recent one was during cold weather in November 2022. I had to wear a winter coat.

In Iowa City, it starts at about 1:00 PM on April 8, 2024 and runs until a little after 3:00 PM. We missed the last one in 2017. The next one visible in the U.S. won’t be until 2044. We think we better see the one next month.

Good Luck Dr. Chris Buresh

Sena was looking up the meaning of a four-leaf clover the other day. You might call it a shamrock although that’s usually reserved for the 3-leaf variety. It’s fitting for St. Patrick’s Day to say the four-leaf clover is special because it’s rare to see one. The four leaves represent faith, luck, love, and hope.

The trouble going on in Haiti is regrettable to say the least. However, it also reminded us of how lucky it was for us to have known one of my former colleagues, Dr. Christopher T. Buresh, MD. He was an emergency room physician at the University of Iowa Hospital until just a few years ago, when he and his family moved to Seattle, Washington. Dr. Buresh is now an Associate Professor in the Department of Emergency Medicine with the University of Washington. He’s also Assistant Program Director of their Emergency Medicine Residency Program.

The connection between Dr. Buresh and Haiti goes back a long way. Many Haitians were lucky he and other physicians volunteered to help provide medical care for them on an annual basis for years.

Chris is really a humble, likeable, and practical guy. He and his family were our next-door neighbors for a while and fascinating things were going on there at times. We remember they built this really cool tree house that sort of looked like it grew out of their main home. They even had an apparatus for a zip line between the two structures. I don’t think the zip line ever actually got installed, but it was intriguing.

He and I sometimes saw each other in the emergency room at University of Iowa Hospital. His energy, compassion, and dedication to patient care were an inspiration to colleagues and learners at all levels. Sena saw one of his presentations about his volunteer work in Haiti. He never mentioned the difficult politics of the situation. He emphasized the work of caring for the Haitians most of all and gave credit to members of the team doing everything they could in that challenging and, I’m sure, sometimes horrifying environment.

It would be easy to just sit and wonder why he left Iowa, and to be sorry about that. On the other hand, when you thing about the 4-leaf clover, you really have to wonder about something else. Maybe he had one in his pocket with all four of what we all want: faith, luck, love, and hope.

New Compound MM-120 Related to LSD Gets FDA Nod

I saw the story in Psychiatric Times about the compound MM-120, which the FDA recently granted breakthrough designation. MM-120 is related to LSD. Breakthrough designation is defined by the FDA as, “…a process designed to expedite the development and review of drugs that are intended to treat a serious condition and preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over available therapy on a clinically significant endpoint(s).”

The compound is made by the company MindMed. This is not to be confused with mind meld, a Star Trek thing related to Vulcans like Spock who can do this telepathic touch thing. The MindMed organization made MM-120 to help treat people who suffer from Generalized Anxiety Disorder. Their study shows the drug could be used as a standalone treatment for the disorder.

According to one story about it published in the December issue of Drug Discovery and Development, it’s not likely MM-120 will be stocked in pharmacies next to the antihistamines and decongestants. The authors believe it would be more likely included in a Risk Evaluation and Mitigation Strategies (REMS) program.

This brings back nightmares about the Clozapine REMS program, which many psychiatrists found almost impossible to enroll in several years ago because of glitches in the web-based application. In fact, the FDA was still not happy with it a couple of years ago, to the extent they had to “temporarily exercise enforcement discretion” over aspects of the program.

Anway, the article goes on to say that the drug has a pretty good safety profile, although concede that the study found the higher dose of MM-120 led to “…perhaps some more challenging experiences….” There were no incidents of suicidal or self-injurious behavior.

I wonder what the “challenging experiences” were, exactly. After all, MM-120 is basically LSD, which was invented in 1938 by the Swiss chemist, Albert Hofmann. He was doing research into crop fungus. He thought it could be used to treat mental illness, even after he accidentally ingested some of it and hallucinated a future in which a guy named Timothy Leary would advise everyone to “turn on, tune in, drop out.”

That whole fungus research issue reminds me of the still unsettled question of how a whole town in France got higher than a kite (leading to some deaths) back in 1951. Ergot poisoning was the initial theory, although later somebody believed it might have been perpetrated as a secret LSD experiment by the CIA. I think the mystery is still unsolved.

However, there is also the history of MK-Ultra, which apparently actually was a classified CIA project running during the Cold War which involved giving LSD to certain unlucky subjects, some of whom didn’t know they were getting it—with disastrous results in some cases.

Just to let you know, I don’t suspect there is some conspiracy between extraterrestrials and the pentagon to get the world population so confused on LSD that we start believing all those crop circles are being created by two guys using a board and a rope. Forget what Agent Mulder says.

Well, The Times They Are A’Changing at the CDC

We just found out that the CDC is, in fact, changing their recommendations on isolation precautions and other guidance for respiratory illness. It turns out the 5 day isolation rule for a positive Covid 19 test is going away. The Respiratory Virus Guidance page has changed as of today.

Sena found out about it from an article in the Wall Street Journal. The rules for health care personnel are not the same as they are for the public. I guess the times theye are a’changing.

CDC ACIP Meeting on Covid 19 Vaccine Additional Dose

The CDC ACIP meeting on February 28, 2024 on the proposal of a Spring booster of the Covid 19 vaccine was interesting and confusing. Initially right after the morning presentations, we were a little confused about whether the committee was targeting only those who got the vaccine booster last fall or everybody. That didn’t make much sense given the concern about low overall uptake of the vaccine.

The presenters also mentioned that getting the Spring Covid booster would be part of a shared clinical decision-making discussion with your doctor, similar to that recommended for the RSV vaccine. That was bewildering because we think that’s part of the reason some people might skip the RSV vaccine, given the news reports last year pointing out you had to have a prescription from a medical provider in some states to get it.

I was pretty interested in learning more about T-cell immunity given the concern about waning which of immunity from vaccines over a few months, which I think was based on neutralizing antibodies from B cells. I thought the CDC web site link to an article about the T-cell immune response suggested that cell mediated immune responses might mean that our immunity might not be waning that quickly. However, one of the presentations, “Evidence to Recommendation” showed a slide indicating that your T-cell immunity gets weaker with age (ref. de Candia P, Prattichizzo F, Garavelli S, Matarese G. T Cells: Warriors of SARS-CoV-2 Infection. Trends Immunol. 2021 Jan;42(1):18-30. doi: 10.1016/j.it.2020.11.002. Epub 2020 Nov 13. PMID: 33277181; PMCID: PMC7664351.)

I’ve read other articles, one of them on the CDC website, which says you may have more durable immunity provided by T-cells, but if I read it carefully, the authors hedge and say that T-cell adaptive immunity may not be as strong when you’re older. (Moss, P. The T cell immune response against SARS-CoV-2. Nat Immunol 23, 186–193 (2022). https://doi.org/10.1038/s41590-021-01122-w).

Later in the afternoon, the committee voted that those who are 65 years old and older should get the spring dose. There was no further discussion of limiting it to only those who got the Covid vaccine in the fall of 2023. There was also no discussion of the shared clinical decision-making detail. The committee upvoted the resolution with a majority.

And yet, the voting question did say: ACIP recommends that persons greater than or equal to 65 years of age “should” (which was changed from “may”) receive an additional dose of 2023-2024 Formula COVID-19 vaccine. The “additional dose” means in addition to the vaccine (monovalent XBB.1.5) given last fall. That’s a relatively select group, when you take the subset of those who are 65 and older.

However, the slides in the “Evidence to Recommendation” had recommended there should be shared clinical decision-making, meaning that you should discuss getting the vaccine with your doctor. However, according to the STAT NEWS article summary of this meeting, substituting the word “should” for “may” would make the conversation with a doctor unnecessary.

Finally, there was no discussion at all of changing the 5-day isolation precaution for those testing positive for Covid-19. If the committee were planning to drop that, as many news agencies recently reported, I would think they’d have discussed it at length at the meeting.

The CDC Director will have to sign off on the additional Covid-19 shot before it’s official.

2/29/2024 Update: CDC Director endorsed the additional dose yesterday.

Hot Mic in the NASA Control Room

By now, everybody probably knows about the Intuitive Machine lunar landing of the Odysseus space craft recently, broadcast from NASA. I happened to have a direct audio hookup to the control room during the hot mic episode which somehow didn’t get broadcast last week.

Sam: OK, how’s Odysseus doing?

Doug: Uh, we slightly overshot the planned landing.

Sam: What? How did that happen?

Doug: Not sure, but I heard a crunching noise.

Sam: Crunching? There’s no crunching allowed on this mission!

Doug: It’s OK, we can hit the gas and put it down in a different spot a little further away.

Sam: How far?

Doug: Not much, about 1,000 miles give or take. Almost there; applying disc brakes—now.

Sam: What is Odysseus’ position now?

Doug: Well, it looks like it sort of fell over on its side. But it’s transmitting images.

Sam: Great! What’s coming across?

Doug: Kind of fuzzy. Wait a sec, just need to adjust the rabbit ears here. What’s that?

Sam: Hard to make it out.

Doug: OK, there. It’s yellow, whatever it is. Stand by. Wait, are those wheels?

Sam: Adjust the focus.

Doug: Whatever this yellow thing or vehicle whatever on wheels is—it’s coming closer. Hey, there’s somebody inside!

Sam: Oh my god; a life form! On the moon! Quick, what’s it doing?

Doug: Wow. It just gave me the finger. Since when are taxicabs on the moon?

Sam: Dammit! Are you telling me that Odysseus didn’t even leave Earth?

Doug: No sir! But that moon rock sort of looks like a manhole cover.

Sam: You’re fired, Doug.

Doug: Does that mean the Odysseus Landing Gala and Orgy is off? I don’t think I can return the Counting Kites THC Magnum Cocktails.

Sam: I guess now we’ll have to refund the 118 million dollars from NASA—minus the cocktail charge.

Thoughts on Upcoming CDC ACIP Meeting

Sena and I are talking about the upcoming CDC meeting on February 28th-29th next week. The agenda looks like they’ll be talking about an “additional dose” of the Covid-19 vaccine.

Given the extent of vaccine fatigue going on, I tried to find a layperson-friendly article on the web about vaccine immunity with details about how long it lasts.

There’s review article from 2022 that helps a little bit. The author says that boosting every few months may not be practical as a long-term strategy. It leads to vaccine fatigue in the population. We all know how low the Covid-19 vaccine uptake has been. The author says that boosters should be offered annually or even less often. There is more to immunity than neutralizing antibodies.

The suggestion of some experts is to offer Covid-19 boosters to whoever wants it. I feel like I’m getting mixed and circular messages when I read that my immunity is “waning,” and I need another one. We’ve gotten every Covid-19 shot since the vaccine campaign began. Experts even differ on whether to call Covid-19 a “seasonal” respiratory virus. That would suggest you could get one shot annually during the respiratory virus season-like the flu shot. Obviously, it’s not that simple if the CDC recommends another Covid-19 vaccine this spring.

And the CDC respiratory virus channel snapshot from February 16, 2024 is a little concerning. A couple of days ago there was a news report that schools in Forest City, Iowa would have to move to remote learning because of outbreaks of influenza, strep throat, and even stomach flu. According to the CDC, respiratory virus activity levels are high all over Iowa, which surprised me this late in the season.

High as a Kite!

We heard about the marketing of a new cannabis product in Iowa. A company called Climbing Kites makes a beverage that contains low concentration THC and it’s legal to buy it as long as the percentage of Delta 9 THC is not above 0.3%. Their website says funny things like “Fly High:  All Buzz, No Booze.” However, it’s not legal to make it in Iowa. So, you just have to make believe you’re drinking it. Just kidding, sort of.

No, seriously, while it’s true it has to be made in Minnesota and shipped back to Iowa, you can buy it in Iowa legally as long as you’re over 21 years old and don’t mind going to prison for 20 years if you’re caught with an open container of the beverage while driving. Relax, that’s a joke. Have another drink! There’s a FAQ web page on the Climbing Kites web site. It’s Iowa’s first THC drink.

That doesn’t mean recreational marijuana is legal in Iowa, at least not yet. Several surrounding states are, though, including Missouri, Illinois, and Minnesota. There’s an interesting article on the future for marijuana legalization in Iowa.

Marijuana is still not legal at the federal level, though. It’s still classified as a Schedule I drug under the Controlled Substances Act. While there is some conflict between the states that legalize recreational marijuana and the federal government, the federal government is not hustling to prosecute in those states.

It’s been a while since I tried marijuana, which really only caused me to think I could feel every blade of grass (the kind you mow) under my feet. It was before the evolution of the paramecium and, as luck would have it, before the invention of matches. This meant I had to chew the marijuana, leading to a gas attack which attracted a pack of dinosaurs. Of course, my gas attack is what led to the first mass extinction of the large reptiles resulting in the formation of the first mammals, who traded the marijuana for cell phones with the Extraterrestrials. It’s hard to know who got over on that deal because mammals came down with the zombie scrolling fixation while the ETs got a case of the stucks, suddenly becoming unable to remember how to drive their spaceships or make basic decisions about abducting cattle or mutilating soybeans. As you know, that led to all the UFO crashes on the planet, eventually making it necessary to hire the Bigfoot clan to re-educate them about how to traverse multiple dimensions in space-time enabling the collection of massive amounts of beef jerky supplies. History tells us this didn’t work out well for the ETs because their mouths are way too small to eat beef jerky.

There are many ways to get high as a kite; the substance high, the runner’s high, the writer’s high, and more. Weighing the good and the bad about them is a difficult task.