Here We Go Again About Antidepressants

Back in August, my colleagues, Drs. George Dawson, MD and Ronald Pies, MD wrote a rejoinder in Psychiatric Times to a review article published in Molecular Psychiatry by J. Moncrieff, Mark Horowitz and others (Moncrieff J, Cooper RE, Stockmann T, Amendola S, Hengartner MP, Horowitz MA. The serotonin theory of depression: a systematic umbrella review of the evidence. Mol Psychiatry. 2022 Jul 20. doi: 10.1038/s41380-022-01661-0. Epub ahead of print. PMID: 35854107.)

The idea that most psychiatrists subscribe to the so-called “chemical imbalance” theory of depression has arisen again in an article by Mark Horowitz on October 7, 2022. Sena alerted me to the article which is getting a lot of attention. There were well over 600 comments and counting about it when we read it on October 7th.

I would like to refer readers to the Dawson and Pies article, “The Serotonin Fixation: Much Ado About Nothing New,” published August 3, 2022. Since the issue about emotional blunting from SSRIs resurfaced again on October 7th, it wouldn’t hurt to review their September 26, 2022, Psychiatric Times article, “Antidepressants Do Not Work by Numbing Emotions.”

Author: James Amos

I'm a retired consult-liaison psychiatrist. I navigated the path in a phased retirement program through the hospital where I was employed. I was fully retired as of June 30, 2020. This blog chronicles my journey.

2 thoughts on “Here We Go Again About Antidepressants”

  1. Wouldn’t it be great if everyone was on the same page and could agree on the possible why and hows? I know people are always going to disagree. But when it comes to depression and why people are depressed and how its dealt with, maybe we wouldn’t lose so many people to it each year if everyone was on the same page and could get it figured out..But thats just my opinion..

    Liked by 1 person

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