Procrastinate on Getting the Covid Vaccine?

This post is sort of my thinking out loud about whether or not I should get the Covid vaccine ahead of this summer that was approved last year as being appropriate to get twice a year by the CDC—once in the fall along with the flu shot and once to protect against the Covid summer surge that some experts argue has been happening every summer since the pandemic onset.

The trouble is that the dominant subvariant is no longer the JN.1 or KP.3.11. The currently dominant circulating bug is LP.8.1 according to the CDC Nowcast chart.

And what confuses me is that one expert still recommends getting the September 2023 updated vaccine, but recommends getting the “bivalent booster.”

And a recent article from the University of Minnesota Center for Infectious Disease Research and Policy (CIDRAP) says that a preprint study (not yet peer-reviewed) says the current Covid vaccine was only 53% effective against hospitalization and 39% medically attended Covid-19. Most patients got the vaccine targeting the XBB.1.5 variant. I think that’s related somehow to the KP.2 variant. I have a vague memory of hearing about the XBB.1.5 during the CDC meeting in September 2023.

I’m a retired psychiatrist, not a retired virologist. The information available to the public seems confusing to me and I imagine I’m not the only one so affected.

The CDC is recommending the 2024-2025 Covid-19 vaccines, which target the JN.1 variant, which is now 0% of circulating variants on the list. But I’m not sure whether the current vaccines would be as protective against the different variants now dominant.

The CDC April indicators show downward trends for test positivity, ER visits, hospitalizations, and deaths.

On the other hand, an August 2024 article from Johns Hopkins warns that Covid-19 rates have consistently risen in July-August risen since 2020. The author says that it’s still unclear whether Covid-19 will continue to have dual seasonality. Other factors that affect this in addition to the emergence of more transmissible variants are human behavior, such as staying in air-conditioned spaces more and traveling.

My big question is should an old guy get the 2024-2025 Covid-19 vaccine or just wait and see, especially in light of the difficult political situation with HHS sounding like it might require new, placebo-controlled trials of some vaccines before “tweaking” them to target more current variants—which could take several months.

But it doesn’t look like there’s a plan to tweak the 2024-2025 Covid-19 vaccine in any case. I’m probably worrying too much, but I’m on the fence. I’m already too good at procrastinating.

Fart Around for Your Health!

How many farts can old fart fart if an old fart walks to fart? I’m sure you’ve heard that one by now after a recent news article suggested that farting while going for a walk on the street after dinner (or any meal) could make you healthier.

It’s not like the only reason is that you get rid of gas and increase intestinal motility to prevent constipation. Some medical experts say it can help control blood sugar.

But you have to fart walk within an hour of finishing a meal to control the glucose spike. You could call it the fart walk sweet spot. There are social implications, especially if the fart walk becomes a growing trend.

What the heck should you wear on fart walks? Windbreakers.

For some reason, Artificial Intelligence (AI) has a lot to say about flatulence, but I usually pass gas over it to move on to other websites to find what might be more reliable information than you get from AI.

While farting a couple dozen times a day can be normal, if you can’t leave your house because of your Frequency Of Odoriferous Farting Impulse (FOOFI), you might want get it checked out.

Eating a lot of fiber-rich foods can lead to digestive problems that can lead to excessive flatulence. Have you noticed that when you’re in a crowd, people tend to sprint away from you? When you’re in an elevator, do people push any button to get off, even if it’s in the basement, or even between floors?

By the way, did you hear about the guy who farted on an elevator? It was wrong on so many levels.

The food choice thing can be the downside of what often happens when you follow the advice of health care professionals who tell you to avoid carbs and eat more fruits and vegetable. This can happen to guys who hit middle age and start to get that big belly. I’m not sure that the diet change will help much, especially since new studies show that guys can produce more belly fat cells as they get older.

What do you call a large, hairy cryptid who eats too much beef jerky? Bigfart.

Certain diseases can be linked to farting, like irritable bowel syndrome, celiac disease, bowel obstruction, and constipation. Funny, I thought farting was supposed to prevent constipation.

What do you say to someone who has made a commitment to daily fart walks? Conflatulations!

The Bouncy Egg Caper on Easter!

Want a scientific excuse to waste an egg? Sena and I found this experiment that uses vinegar to make a bouncy egg yesterday.

We put a whole raw egg into a bowl full of vinegar and let it sit for 24 hours. Initially, a couple of hours after we put the egg in the bowl of vinegar, Sena noticed pressure building up in the bowl. Even though the lid was on, vinegar was starting to leak out so she set it inside a larger bowl.

I started to worry a little about whether enough pressure would build to blow the lid off in an explosion—but it never happened.

I think a lot of people get this idea around Easter. The main thing that happens is the vinegar (a weak acid) eats away at the egg shell (which is made of calcium carbonate) until the shell dissolves. Carbon dioxide gas bubbles form. It leaves a rubbery membrane behind. The water in the vinegar diffuses across the membrane.

The egg had a lot of bubbles all over it and was visibly larger. The shell had completely dissolved—and it bounced! Sena tried bouncing it from higher and higher levels until the inevitable splat. All that was left was the yolk and the membrane.

It kind of reminds me of the morgue autopsy scene in the 1997 Men in Black movie between the deputy medical examiner Dr. Laurel Weaver and Agent J (everything reminds of Men in Black movies):

Dr. Weaver: Feel that? Where the eggshell should be? Notice anything strange?                 

Agent J: No, all fine.       

Dr. Weaver: Doctor, the whole shell is missing.                  

Agent J: Well, of course. That’s obviously the first thing I noticed. What I was pointing out is the fact that there are no… pieces…of it left. You know, so the shell is intact; wherever it is whole, somewhere. That we can be sure of.

One Legged Clowning Again

I noticed the other day that I was having trouble doing the one leg stand. It has been getting harder to sustain it past 10 seconds even. It’s not like I’ve been laying off exercising, including the one leg stand. Hey, I can even do a one leg sit to stand (barely). I posted about the one leg stand, including a video, about 2 years ago.

I found another news item and study about old farts like me and it included a new recommendation about the one leg stand. According to this study, if you can’t do a one leg stand for more than 5 seconds, you’ve got one leg in the grave. If you can do 30 seconds, then you’re all good.

So, I practiced a little more and I even tried the one leg juggling trick, which I also tried two years ago—and clearly faked on a video. Well, one leg clowning is back—and this time it’s for real. I think the Latin quote Ars Longa, Vita Brevis fits for this activity. This one leg stand thing is a skill and you have to work at it, even as you age and your life grows shorter.

I still don’t know if this would be called aging gracefully?

References:

Rezaei A, Bhat SG, Cheng CH, Pignolo RJ, Lu L, Kaufman KR. Age-related changes in gait, balance, and strength parameters: A cross-sectional study. PLoS One. 2024 Oct 23;19(10):e0310764. doi: 10.1371/journal.pone.0310764. PMID: 39441815; PMCID: PMC11498712.

Araujo CG, de Souza E Silva CG, Laukkanen JA, Fiatarone Singh M, Kunutsor SK, Myers J, Franca JF, Castro CL. Successful 10-second one-legged stance performance predicts survival in middle-aged and older individuals. Br J Sports Med. 2022 Sep;56(17):975-980. doi: 10.1136/bjsports-2021-105360. Epub 2022 Jun 21. PMID: 35728834.

CDC ACIP Meeting Today on Vaccines

There’s a CDC ACIP Meeting scheduled to start at 8:00 AM EST today (caught me off guard). The slides are here.

Noteworthy: Dr. Denise Jamieson, MD, MPH is chair of the CMV Working Group. She is Vice President for Medical Affairs and the Tyrone D. Artz Dean, Roy J. and Lucille A. Carver College of Medicine at University of Iowa. In the Q&A session following the Covid-19 vaccine presentation, Dr. Jamieson expressed a preference for a universal recommendation (citing implementation and uptake challenges, which other attendees mentioned as well) for the Covid-19 vaccine as opposed to a risk-based or permissive recommendation. See slide labeled “Discussion” below:

There was no vote scheduled for today’s meeting on the Covid-19 vaccine.

The presentation by Moderna on the new Covid-19 vaccine, mRNA-1283, was helpful. I gather there will be an FDA meeting about it in June.

The Svengoolie Movie: The Deadly Mantis

I watched the 1957 giant insect movie, “The Deadly Mantis” last night on the Svengoolie TV show, and Sena watched some of it. At times, it was a little hard to tell if this was a romantic comedy or a giant insect horror flick. The reporter Marge Blaine (played by Alix Talton) and Colonel Joe Parkman (played by Craig Stevens) had this fling going on which sometimes took precedence over the huge, deadly papier-mâché praying mantis.

There’s a lot of stock film footage of the military and important military radar dividing lines across the northern hemisphere including the DEW Line (standing for Distant Early Warning Line) which were real. There were a couple of shots of Greenland, which is important to you know which U.S. President—who was probably unaware at the time of the dangerous mantis unthawed from its icebound prison in the North Pole.

If you look carefully in the upper right-hand side of the frame at the 34:48-time mark, in the Internet Archive black and white copy of the film, you’ll see an important goof that Svengoolie pointed out (which I missed at first). It’s the shadow of the large microphone and boom which shows up as Marge and Dr. Nedrick Jackson are leaving the room (Jackson is played by William Hopper, cue Perry Mason music because he played detective Paul Drake on that TV Show). It’s interesting that the Perry Mason show was starting the same year this movie was filmed.

One detail never specified about the monster is its exact species. We can’t tell if it’s the European praying mantis or the invasive Chinese Mantis. That’s not important for the movie, but again, it might be important on the world’s current political stage. Most entomologists advise destroying the eggs of the Chinese Mantis. I don’t know if tariff escalation would work. I think it’s hard to distinguish different mantis species eggs apart and we also don’t know the gender of the giant mantis in the movie.

That’s an important detail, which is only delicately referred to in the film as Dr. Jackson reads aloud from a book about the insect’s mating process, which invariably concludes by the female biting off the head of the male and often eating him (called sexual cannibalism). In the movie, Dr. Jackson reads aloud a gentler description, “The female is larger than the male and invariably destroys her mate when he’s fulfilled his function in life.”

There are interesting parallels to the mantis in the way the male and female lead actors interact with each other in the movie. Colonel Parkman and Dr. Jackson both behave like typical male chauvinists, and Marge never bites their heads off. But the romance doesn’t go that far. Marge dances with the soldiers but there’s no scene with Elvis Presley dancing and singing “Heartbreak Hotel.”

And there’s no time for any of that because the giant mantis is too ravenous after being cooped up for thousands of years in an iceberg. All it wants is breakfast: “Two humans on a raft and wreck’em” or is it “Two humans, dummy side up”? Whatever.

Anyway, the ferocious mantis ends up sort of like the bad-tempered giant cockroach in the 1997 movie “Men in Black.” Agents K and J speed through the New York Brooklyn-Battery Tunnel and have a showdown. The soldiers in The Deadly Mantis have their showdown with the monster in New York also, but it’s in what’s called The Manhattan Tunnel, which I found out doesn’t even exist.

But the parallels don’t stop there. Just before that, the terrifying insect climbs the Washington Monument (to get to the top, of course) and buzzes the White House. During the search for the bad bug, the military brass order that every U.S. citizen in the area report any “Unusual Flying Object,” in other words every UFO.

That means the sequel to both movies would need an extraterrestrial giant, bad-tempered female cockroach and mantis hybrid looking to bite the head off a suitable mate who crash-lands her UFO in the 51st state (formerly Canada) leading to the emergency mobilization of Men in Black who partner with Red Green and the rest of the Possum Lodge members to use duct tape and bug spray to overcome the beast and finally ensure peace by neuralyzing everyone in the world using a souped-up satellite owned by Elon Musk. Svengoolie will tell jokes.

It just goes to show you, we’re humans, but we can change, if we have to…we guess.

University of Iowa Will Lead NASA Space Mission to Learn the Music of the Spheres

The big news for University of Iowa will be a NASA satellite mission to investigate how solar wind interacts with Earth’s magnetosphere. You can read the whole fascinating story in this issue of Iowa Magazine.

According to the story, “twin spacecraft known as TRACERS—Tandem Reconnection and Cusp Electrodynamics Reconnaissance Satellites—will begin their journey to study Earth’s mysterious magnetic interactions with the sun. The satellites will be packed with scientific instruments along with two small, but meaningful, tokens.”

The two small tokens happen to be purple guitar picks that belonged to University of Iowa physicist, Craig Kletzing, who died from cancer in 2023. Kletzing and colleagues got a $115 million contract from NASA for TRACERS. It’s the largest research award in University of Iowa history.

Kletzing played guitar in a few bands, and one them was named Bipolar—which is the only connection to psychiatry that I could see. He was dedicated to work in basic science, and he was often heard to ask “How can we make this simpler?” referring to chunking big scientific challenges into manageable goals. He was a rare person in that he was both a brilliant scientist and a great teacher. One example of his work ethic was that he skipped a meeting with NASA’s top brass in order to deliver a morning lecture on introductory physics to 275 students.

The members of the UI TRACERS team call the project “Craig’s mission.” I’m pretty sure he would have called it a team effort “… to help scientists better understand the powerful forces harmonizing throughout the universe—something the ancient Greeks described as the music of the spheres.”

And that’s what the purple guitar picks represent.

SAINT Therapy for Treatment Resistant Depression at The University of Iowa

First of all, if you looked up Saint therapy for depression, you might have accidentally found information on Saint Dymphna, the Catholic patron saint of those living with mental illness.

Actually, SAINT stands for Stanford accelerated intelligent neuromodulation therapy. It’s a personalized protocol for using transcranial magnetic stimulation (TMS) to treat severe depression. The University of Iowa is the first academic center to offer it in the Midwest.

This is a big step forward from the days many years ago when we were starting use right unilateral electrode placement for applying electroconvulsive therapy (ECT) to treat depression because it was thought to lead to fewer cognitive problems post-treatment.

SAINT is a game changer according to Dr. Nicholas Trapp, MD, assistant professor of psychiatry, who describes it as a method to pinpoint the best location in each patient’s brain to target with TMS to treat major depressive disorder. The procedure is quick and recovery from depression can be sustained for months.

Kudos to The University of Iowa. And maybe thanks to Saint Dymphna.

What is Foreign Language Syndrome?

I found a very interesting news outlet report about a condition called Foreign Language Syndrome (FLS) which you have to distinguish from Foreign Accent Syndrome (FAS). I wrote a post about that a few years ago. The latter is common by comparison with FLS. FAS is a tendency to speak with a foreign inflection, not speak or be unable to speak a different language, which is what FLS would be.

There are a handful of cases, all within the last 20 years, most of them associated with receiving anesthetic agents prior to surgeries. All could speak more than one language; in other words, they didn’t wake up from anesthesia with the ability to speak another language they never learned before.

I could find only one web link to a case report (see below) about FLS, published about 3 years ago, which is what the news story was about. In fact, the authors of this report describe the case of a 17-year-old male who suffered FLS (forgot his native Dutch language, but who also spoke English) after knee surgery, noting that the other known cases were subjects of news stories.

Humbaba qabDaj luchenmoH Humanpu”e’ ‘ej ghaytan tera’ tach ‘elpu’ jupwI’ ‘e’ vIHon. chaq wa’ Qib rurbogh taS QIpmey, Huj jaghmey luchoHlu’ta’ ‘ach, qaStaHvIS mInDu’ vISuq.

Oops, sorry, accidentally started babbling in Klingon. I meant to say:

Based on the case report, FLS might be an emergence delirium, caused by the choice of a particular anesthetic agent. Emergence delirium is delirium caused by waking up from anesthesia after surgery, which I’ve experienced a couple of times, although I have difficulty remembering the episodes.

Kiu(j) ne eksklud alia kaŭz por FLS, kvankam verŝajne, plimulto retrov plimalpli tute post du tagojn antaŭ la operacio.

Rats, happened again, with Esperanto. What I meant:

That doesn’t rule out other causes for FLS, although it looks like most people recover more or less completely after a couple of days out from the surgeries.

More studies are needed.

Reference: Salamah, H.K.Z., Mortier, E., Wassenberg, R. et al. Lost in another language: a case report. J Med Case Reports 16, 25 (2022). https://doi.org/10.1186/s13256-021-03236-z

The 2024 Distinguished Education Lecture by Russell Ledet, MD, PhD

Last year, I wanted to present this Distinguished Education Lecture by Dr. Russell Ledet, MD, PhD, given during Martin Luther King Jr. Celebration of Human Rights week. It took a while for my message to the University of Iowa to get through channels, but I want to thank Audra M. King, the Administrative Services Coordinator for the Office of Student Affairs and Curriculum in the University of Iowa Carver College of Medicine for her help in getting it into a YouTube format that allows the general public to see and hear Dr. Ledet’s presentation.

I wrote a post in February last year about how impressed I am with Dr. Ledet as a leader. Now you can hear him tell his own inspirational story.