How about some good news? This just in, University of Iowa Physician-Scientist, Dr. Michael Welsh, wins the 2025 Lasker Award for his research on cystic fibrosis.
His work and the work of two other researchers with whom he’ll share the award set the stage for the development of new drugs which saves the lives of those who suffer from cystic fibrosis.
I learned from the article that the cystic fibrosis gene was discovered in 1989; I was a second-year medical student then. Since then, the development of new treatments has meant that many people who died in early adulthood now can live into their 80s.
Join Dr. Clancy and his guests, Drs. Evelyn Ross-Shapiro, Sarah Shaffer, and Emily Walsh, as they discuss the complex set of symptoms and treatment options for those with significant symptoms from menopause. CME Credit Available: https://uiowa.cloud-cme.com/course/courseoverview?P=0&EID=81895 Host: Gerard Clancy, MD Senior Associate Dean for External Affairs Professor of Psychiatry and Emergency Medicine University of Iowa Carver College of Medicine Guests: Evelyn RossShapiro, MD, MPH Clinical Assistant Professor of Internal Medicine Clinic Director, LGBTQ Clinic University of Iowa Carver College of Medicine Sarah Shaffer, DO Clinical Associate Professor of Obstetrics and Gynecology Vice Chair for Education, Department of Obstetrics and Gynecology University of Iowa Carver College of Medicine Emily Walsh, PharmD, BCACP Clinical Pharmacy Specialist Iowa Health Care Financial Disclosures: Dr. Gerard Clancy, his guests, and Rounding@IOWA planning committee members have disclosed no relevant financial relationships. Nurse: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this activity for a maximum of 1.00 ANCC contact hour. Physician: The University of Iowa Roy J. and Lucille A. Carver College of Medicine designates this enduring material for a maximum of 1.00 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Other Health Care Providers: A certificate of completion will be available after successful completion of the course. (It is the responsibility of licensees to determine if this continuing education activity meets the requirements of their professional licensure board.) References/Resources:
This is a fascinating topic and the discussion ran for close to an hour, which is longer than usual because there’s a lot to say about it. The substances include a lot of chemicals that are not illegal and, in some cases, easily available in convenience stores and gas stations. In fact, the name for one of them is gas station heroin, which is tianeptine, approved in other countries as an antidepressant.
The discussion also included substantial information (or maybe better said, lack of enough information) about bath salts (usually cathinones), kratom, and something I’ve never even heard of: diamond shruumz (chocolate bars which can contain various substances not limited to psilocin). Remember that guy who chewed the face off of somebody in Miami in 2012? That was attributed to intoxication with bath salts.
This is way beyond the 1970s stuff like window pane or blotter (LSD) and pot. Many people end up in emergency rooms for evaluation of what looks like poisoning from multiple drugs. The stickler is the possibility that they got poisoned from something bought at a convenience store. Often it’s difficult to tell what the person ingested.
One of the takeaways from this podcast is that, whenever possible, try to get a history from the patient. They might just tell you what you need to know.
Sena went over to ForeverGreen, a popular landscaping and garden center locally, to see the butterfly house. She got pictures and video clips which showed the monarch butterfly management operation they have. They have quite a conservation program, including a large monarch butterfly house enclosure along with demos of life cycle stages. The butterfly house is just part of the deal and it’s open to the public. It opened in June of this year and runs until September 14th. The schedule shows there’ll be a big release then and possibly even tagging prior to that. You might want to call ahead and check to see if they’re still going to tag the monarchs.
I think this is also a good way to rehabilitate Bigfoot’s image because they could be sort of like ranch hands tending to the monarch as they go through their life cycle. The monarchs migrate to Mexico every fall. You can learn more about the monarch watch program and why many people believe the monarchs are at risk of extinction.
As I announced yesterday, we put together a short YouTube video on the tagged monarch butterfly we saw yesterday at Terry Trueblood Recreation Area, with the help of another guy who pointed it out to us. This was a lot of fun because we didn’t know anything about the monarch tagging project.
The tagging project is just one part of a comprehensive educational and research program. One interesting section on bugs that feed on milkweed talks about milkweed beetles, but I didn’t find anything about milkweed bugs until I checked another site. It sounds like splitting hairs, but they’re not the same insect although they both feed on the milkweed, which the monarch larvae eat.
I got a photo of the milkweed bugs. Although the pile of them on the milkweed look like two different insects, the smaller ones are just younger versions of the same bug. I don’t think there were milkweed beetles on the milkweed plant I saw.
The other interesting thing is how to tell male from female monarchs. I’m not confident I can do that, although there is a video I posted yesterday (made by the Monarch Watch team) which tells you how to distinguish them.
We think the tagged monarch we saw might be a male, but I wouldn’t bet on it. We saw another monarch (which is featured in the video) which could be a female.
There is a fall open house at Kansas University West Campus in Lawrence, Kansas on Saturday, September 13, 2025.
We’re both pretty excited today because we found a tagged monarch butterfly with a guy’s help out on the Terry Trueblood Trail. We saw quite a few monarch butterflies around the flowers and saw a man spending a lot of time getting a video of one of them with his smartphone. Sena remarked about how nice all the flowers were and he pointed to the butterfly and said it was tagged.
We had no idea what he meant until after we filmed the butterfly and saw this tag with numbers and letters printed on its wing. Sena got a really good shot of it and we were able to read the code.
Then we discovered the website for tracking monarch butterflies.
You can actually report the tagged butterfly to MonarchWatch.Org. We had never heard of the Monarch Watch Tagging Program, which got started in 1992 to track the monarch’s migration pattern.
We’re not certain of the sex of the monarch we saw today (which is part of the reporting process), but that’s OK. We can just enter “Unknown.” On the other hand, you can find instructions on line. We plan to make a video of our walk tomorrow with the monarch as the star, but I wanted to give you a heads up about the most exciting part of it today.
I’ve been checking the Centers for Advisory Committee schedule on their website for weeks and the only way I found out there is an upcoming meeting is on the Federal Register schedule. Sena found it in a news outlet story. As of this morning around 9 a.m., there was no announcement on the CDC website yet. That may change later today.
According to the Federal Register, the CDC ACIP will hold a meeting on September 18, 2025, from 10 a.m. to 5 p.m., EDT, and September 19, 2025, from 8 a.m. to 4 p.m., EDT.
Under Supplementary Information:
“The agenda will include discussions on COVID-19 vaccines; Hepatitis B vaccine; measles, mumps, rubella, varicella (MMRV) vaccine; and Respiratory Syncytial Virus (RSV). The agenda will include updates on ACIP Workgroups. Recommendation votes may be scheduled for COVID-19 vaccines, Hepatitis B vaccine, MMRV vaccine, and RSV. Vaccines for Children (VFC) may be scheduled for COVID-19 vaccines, Hepatitis B vaccine, MMRV vaccine, and RSV. Agenda items are subject to change as priorities dictate. For more information on the meeting agenda, visit https://www.cdc.gov/acip/meetings/index.html.”
However, I also noticed a news article posted by the Center for Infectious Disease Research and Policy (CIDRAP) indicating that the meeting might be postponed because of the recent upheaval around vaccine policy and personnel.
This meeting’s actual timing and schedule items could be moving targets.
The Svengoolie show last night was the 1957 Hammer production “The Curse of Frankenstein” starring the 3 stooges. Actually, this film was no laughing matter and this was my first time (and last time) seeing it.
That’s not saying it’s a “bad” movie. It’s just tough to come up with anything comical to say about a gothic horror flick that was inspired by Mary Shelley’s novel, “Frankenstein; or, The Modern Prometheus.”
I’ve not read Mary Shelley’s novel and I only skimmed the Encyclopedia Britannica entry. That’s good enough for an old guy pretending to be a movie reviewer.
What hooked me, though, early on the film was a short dialogue between Paul Krempe (Robert Urquhart) and Elizabeth Lavensa (Hazel Court). Paul describes Victor Frankenstein (Peter Cushing) in contemptible and scary terms, to which Elizabeth reacts by saying that Victor is either “wicked or insane.” Paul answers that Victor is neither—which struck me as odd.
I would have no trouble saying Victor is evil, but what do I know? On the other hand, I ran across a couple of web articles that mentioned “psychopath” as a suitable label for someone who thinks nothing of pushing an old man like the scientific scholar Professor Bernstein (Paul Hardtmuth) over a banister to kill him in order to dig his brain out of his skull to insert into a do-it-yourself hodgepodge of spare body parts in an experiment to create a living being.
Victor, from the time he first meets Paul, presents as an insufferable, entitled brat lacking a conscience and by the time he reaches adulthood he’s the perfect example of someone with the most creepily severe case of antisocial personality disorder (ASPD) imaginable.
He gets the housekeeper Justine (Valerie Gaunt) pregnant, tricks her into entering the laboratory where the monster (Christopher Lee) kills her, marries Elizabeth and then abandons her on their wedding night in order to cheat in a cribbage game with the monster.
He pretends to bury the monster in the woods after Paul kills it by shooting it in the eye with an AK-47—then sneaks back to dig it up, carry it back to the lab and reanimates the wreck. He proudly shows it off to Paul, who throws up on him. This makes no difference to Victor who is always smeared with dirt anyway because he hangs out in morgues, graveyards, and golf courses (“as he approaches this critical putt, somebody leaps out and cuts off his feet”), filching eyes, hands, Adams apples and what have you to assemble and repair the monster.
There are big differences between Shelley’s monster and Hammer’s creature—the latter doesn’t speak at all while the former is eloquent. Hammer’s creature can barely stand up or sit down on command while Shelley’s monster can do triple axels skating across the Arctic ice as Victor pursues him.
During the movie, my mind often wandered off to memories of Mel Brooks’ “Young Frankenstein.”
I recently got my first and only comment on a blog post I posted on March 30, 2019 about toeless mourning doves which were visiting our backyard deck of a house in which we lived previously. I also found an article published about the issue later that year in December of 2019, which is about pigeons losing toes. Pigeons and mourning doves are not exactly the same (although they are relatives within the same family), but apparently pigeons are thought by the authors of the article to lose their toes because of urban pollution.
The commenter is from West Texas who has seen toe deformities, notes that it’s a new problem to him (never saw it prior to this year), remarks that the toe deformities were visible in newly hatched birds and further suspects the problem is more complicated than exposure to stringfeet or frostbite injury.
When I searched the web for more information, what appeared is my 2019 blog post at or near the top of the page and little else. There was one news item about the issue published in 2021 suggesting the problem of missing toes in doves at that time was probably due to frostbite from a winter storm in North Texas.
We haven’t seen any mourning doves lately. They don’t frequent our new property, which is actually close to the same neighborhood where we observed the toeless birds several years ago.
So, the mystery deepens. If anyone has new information, let me know.
New reference:
Frédéric Jiguet, Linda Sunnen, Anne-Caroline Prévot, Karine Princé,
Urban pigeons losing toes due to human activities,
Abstract: Measuring the impacts of urban pollution on biodiversity is important to identify potential adaptations and mitigations needed for preserving wildlife even in city centers. Foot deformities are ubiquitous in urban pigeons. The reasons for these mutilations have been debated, as caused by frequenting a highly zoonotic environment, by chemical or mechanistic pigeon deterrents, or by necrosis following stringfeet. The latter would mean that pigeons frequenting pavements with more strings and hairs would be more exposed so subject to mutilations. We tested these hypotheses in Paris city (France), by recording the occurrence and extent of toe mutilations on samples of urban pigeons at 46 sites. We hypothesized that mutilations would be predicted by local overall environmental conditions, potentially related to local organic, noise or air pollutions, so gathered such environmental predictors of urban pollutions. We showed that mutilations do not concern recently fledged pigeons, and that their occurrence and frequency are not related to plumage darkness, a proxy of a pigeon’s sensitivity to infectious diseases. Toe mutilation was more frequent in city blocks with a higher degree of air and noise pollution, while it tended to increase with the density of hairdressers. In addition, the number of mutilation on injured pigeons was higher in more populated blocks, and tended to decrease with increasing greenspace density, and to increase with air pollution. Pollution and land cover changes thus seem to impact pigeon health through toe deformities, and increasing green spaces might benefit bird health in cities.
One sentence summary
Toe mutilation in urban pigeons is linked to human-induced pollution.
Keywords: Columba livia; Feral pigeon; Toe mutilation; Stringfeet; Urban pollution
OK, so Sena picked all the patio tomatoes and most of them didn’t turn red, especially the slicers. She’s done with growing vegetables. I saw an article about why tomatoes don’t turn red and it makes sense. The featured image shows the patio tomatoes in the plastic bucket for comparison with the red store-bought tomatoes. The bigger green ones are the slicers.
I’m a little leery about eating green tomatoes. According to another article, it’s safe to eat them as long as you don’t gorge on a lot of them. You’d have to eat about a pound and a half to get the amount of some compounds called solanine, atropine, and tomatine, which would turn you into an extraterrestrial. And University of Iowa researchers discovered green tomatoes have an alkaloid called tomatidine which may actually build muscles (don’t tell teenage boys!).
I just noticed something about one of my YouTube videos that I made sort of as a combination gag and educational piece about pseudobulbar affect. It needed a couple of updates—one of which is minor and which I should have noticed 10 years ago when I made it.
It’s a pseudo-rap performance (badly done, I have to agree although it was fun to make), but it’s one of my most watched productions; it has 18,000 views.
One minor update is about the word “Dex” in the so-called lyrics of this raggedy rap song (see the description by clicking on the Watch on YouTube banner in the lower left-hand corner). It stands for dextromethorphan, one of the ingredients along with quinidine in Nuedexta, the medication for pseudobulbar affect. Dextromethorphan has been known to cause dissociation when it’s abused (for example, in cough syrup).
The most important update is about Dr. Robert G. Robinson, who I joked about in the piece. He passed away December 25, 2024. He was the chair of The University of Iowa Dept. of Psychiatry from 1999-2011. He was a great teacher, mentor, and researcher. He published hundreds of research papers and books on neuropsychiatric diseases like post-stroke depression and pseudobulbar affect. He lectured around the world and was widely regarded as a brilliant leader in his field.
Early in my career in the department, I left twice to try my hand in private practice psychiatry. Both times Dr. Robinson welcomed me back—warmly. He was my co-editor of our book, Psychosomatic Medicine: An Introduction to Consultation-Liaison Psychiatry, published in 2010.
All who worked with Dr. Robinson will never forget him.
Go Retire Psychiatrist 