Thoughts on Long Covid

I read Dr. Ron Pies, MD’s essay today, “What Long COVID Can Teach Psychiatry—and Its Critics.” As usual, he made thought- provoking points about the disease concept in psychiatry. What I also found interesting was the connection he made with Long Covid, a debilitating illness. He cited someone else I know who was involved with a group assigned to create a working definition for it—Dr. E. Wes Ely, an intensive care unit physician at Vanderbilt University in Nashville, Tennessee.

I remember when I first encountered Dr. Ely, way back in 2011 when I was a consulting psychiatrist in the University of Iowa Health Care general hospital. I was blogging back then and mentioned a book he and Valerie Page and written, Delirium in Critical Care. Back then I sometimes read parts of it to trainees because I thought they were amusing:

“…there is a clearly expressed opinion about the role of psychiatrists. It’s in a section titled “Psychiatrists and delirium” in Chapter 9 and begins with the sentence, “Should we, or should we not, call the psychiatrist?” The authors ask the question “Can we replace them with a screening tool, and then use haloperidol freely?” The context for the following remarks is that Chapter 9 is about drug treatment of the symptoms and behaviors commonly associated with delirium.”

I would point out that the authors say, while acknowledging that the opinions of psychiatrists and intensivists might differ, “…we would advocate that a psychiatrist should be consulted for patients already under the care of a psychiatrist or on antipsychotic medications”. Usually, in most medical centers in the U.S.A. a general hospital consultation-liaison psychiatrist sees the delirious inpatient rather than the patient’s outpatient psychiatrist. And many delirious patients don’t have a previous formal history of psychiatric illness and so would not have been seeing an outpatient psychiatrist in the first place.” (Page, V. and E.W. Ely, Delirium in Critical Care: Core Critical Care. Core Critical Care, ed. A. Vuylsteke 2011, New York: Cambridge University Press).

I’m pretty sure I got an email from Wes shortly after I posted that, with his suggestion that I write more about the delirium research he was doing. He sent me several references. I met him in person at a meeting of the American Delirium Society later on and attended an internal medicine grand rounds he presented at UIHC in 2019, “A New Frontier in Critical Care Medicine: Saving the Injured Brain.” He’s also written a great book, “Every Deep-Drawn Breath.”

Anyway, Dr. Ely and others were tasked by the Administration for Strategic Preparedness and Response and the Office of the Assistant Secretary of Health in the Department of Health and Human Services tasked the National Academies of Sciences, Engineering, and Medicine (NASEM) with developing an improved definition for long Covid.

At first, I was puzzled by the creation of criteria that essentially defined Long Covid as a disease state which didn’t even necessitate a positive test for Covid in the history of patients who developed Long Covid. I then read the full essay by Family Medicine physician, Dr. Kirsti Malterud, MD, PhD, “Diagnosis—A Tool for Rational Action? A Critical View from Family Medicine.”

I was hung up on the dichotomy between physical illness and somatization and thought the Long Covid definition posed a dilemma because it purposely omits any need for an “objective” test to verify previous Covid infection, making the Long Covid diagnosis based completely on clinical grounds. The section on persistent oppositions (dichotomies) was helpful, especially the 2nd point on the dichotomy of the question of whether an illness is physical or psychological (p.28).

The point on how to transcend the dichotomy was well made. I guess it’s easy to forget how the body and mind are related when a consultation-liaison psychiatrist is called to evaluate somebody for “somatization.” Often that was the default question before I ever got to see the patient.

Still, the person suffering from Long Covid often doesn’t seem to have a consistently effective treatment and may stay unwell or even disabled for months or years. Social Security criteria for disability look well-established.

I can imagine that many persons with Long Covid might object to have their care transferred to psychiatric services alone. I can see why there are Long Covid clinics in several states. It’s difficult to tell how many and which ones have psychiatrists on staff. The University of Iowa calls its service the Post Covid Clinic and can refer to mental health and neuropsychology services. On the other hand, a recent study of how many Long Covid clinics are available and what they do for people showed it was difficult to ascertain what services they actually offered, concluding:

“We find that services offered at long COVID clinics at top hospitals in the US often include meeting with a team member and referrals to a wide range of specialists. The diversity in long COVID services offered parallels the diversity in long COVID symptoms, suggesting a need for better consensus in developing and delivering treatment.” (Haslam A, Prasad V. Long COVID clinics and services offered by top US hospitals: an empirical analysis of clinical options as of May 2023. BMC Health Serv Res. 2024 May 30;24(1):684. doi: 10.1186/s12913-024-11071-3. PMID: 38816726; PMCID: PMC11138016.)

I’m interested in seeing how and whether the new Long Covid definition will be widely adopted.

Sena + Prune Juice = Space Trip?

Sena has been drinking her prune juice and I presume she’s regular. Besides that, she could be an excellent astronaut.  There was a small study by scientists that seemed to show that mice who ate prunes could be protected from space radiation.

I think you’d have to eat a lot of prunes for that. Being regular is one thing, but being less susceptible to the dangers of space travel to places like Mars might mean a serious commitment to prunes beyond human endurance.

It makes me wonder how extraterrestrials tolerate it. We’re always depicting them as humanoid on TV and in movies. Maybe they already know about this. It would give abduction a whole new meaning.

Anyone notice a prune shortage?

Svengoolie Movie Next Saturday “Invaders from Mars” Triggers Memories!

The Svengoolie TV show movie next Saturday will be “Invaders from Mars” released in 1953 and it triggered some memories. One of them is when I was a little kid. I think I saw parts of it on TV while I was supposed to be down for a nap. I recall seeing these burly guys in green body suits trotting stiff-legged through tunnels. Their gait is something I can’t forget—no matter how hard I try. For a long time, I thought I had just been dreaming. But I’m pretty sure the nightmare was real because when we saw the movie last year on the Svengoolie show, those Martians looked familiar.

The other memory is of a TV public service announcement (PSA) commercial in the early 1970s. I managed to find a YouTube of it that reminded me of the leader of the Martians. He was in a clear globe and the green guys carried him around. He was just a head with tentacles. He was the leader and was very much ahead of his assistants in an evolutionary sense. At least I think that was the idea. He was basically the brains of the extraterrestrial population. He did all the thinking and planning—but he was stuck in this globe.

Anyway, the commercial is from 1971 and it’s a PSA from the President’s Council on Physical Fitness and Sports. The commercial shows how we’d be by the year 2000 if we didn’t shape up, literally. Richard Nixon was President; during his presidency Apollo 11 landed on the moon—and he resigned from office because of the Watergate scandal. Anyway, food for thought for the upcoming film, “Invaders from Mars,” which probably has a message about leadership.

CDC ACIP Meeting Today on Covid-19 Vaccine

We watched the Covid-19 vaccine part of today’s meeting this morning. I thought it got off to sort of a rough start, mainly with technical difficulties. I can’t recall any other meetings in which the camera flipped back and forth oddly between speakers and their slides. I thought that was distracting.

The question-and-answer periods ran too long which put them behind schedule. One member of the original 8 committee members, Dr. Michael Ross, was missing from the CDC roster. There were news articles about his withdrawing after a review of financial holdings.

While most of the Covid-19 presentation was review, I thought it was too bad that ACIP Chair Dr. Martin Kulldorff announced there would be no vote on the Covid-19 vaccine today. He also said that the ACIP committee would look forward to the missing Evidence to Recommendations (EtR) material in the fall. Dr. Adam MacNeil, the presenter of the Covid-19 vaccine review, admitted that the EtR was not finished. I was not clear on why.

I didn’t really see the point of Dr. Kulldorff’s giving a rather long speech about why he was fired from Harvard after he refused to get the Covid-19 vaccine. I would much rather have heard him give details about his emphasis on the importance of conducting controlled trials (I think he meant placebo-controlled?) and posing this as a question to Dr. MacNeil. I think this is what led to Dr. MacNeil’s response which implied that they would take too long to produce actionable results (I might be putting words in his mouth but that’s my interpretation)—which could lead to saving more lives. It looked like a rather awkward moment.

Dr. MacNeil reviewed the FDA approval of using a JN.1 lineage vaccine at the VRBPAC meeting in May and also mentioned the FDA leadership preference for the LP.8.1 variant. I noticed the CDC variant genomic tracker today shows that the new kid on the block, NB.1.8.1, is now just as prevalent or more prevalent as LP.8.1. They’re both from the JN.1 lineage.

Some of the questions from the newly appointed committee members were over my head. But in all fairness, one of the members asked a question which not only I didn’t get but that Dr. MacNeil said he didn’t quite understand either.

So far, we’re planning to watch the influenza vaccine presentation tomorrow morning. I’m not sure why there’s a vote on thimerosal in the flu vaccine tomorrow but there was no vote on the Covid-19 vaccine today.

Sena Gets her Measles Vaccine-and Will Not Be Defeated!

Sena got a measles vaccine booster today just to be on the safe side given the increase in the number of measles cases all over the country, including Iowa.

The history of the measles vaccine is fascinating by the way. It can make it challenging to figure out who might need a booster.

Despite the mild headache from the shot—she won our cribbage match again. She will not be defeated!

CDC Advisory Committee Meeting on Vaccines Starts Tomorrow

The CDC ADVISORY COMMITTEE ON IMMUNIZATION PRACTICES (ACIP) is scheduled to begin their meeting tomorrow at 10:00 AM ET despite US Senator Bill Cassidy’s recommendation that it be postponed due to concerns about the lack of experience of the committee members and because there is not yet confirmation of a new CDC Director.

In fact, the CDC Director nominee, Dr. Susan Monarez, of Wisconsin, is scheduled for her confirmation hearing at the same time as the start of the CDC ACIP meeting tomorrow morning at 10:00 AM ET. Dr. Monarez would be the first CDC director “…in decades…” (according to a report posted in The Hill in May) who has neither previously worked at the CDC “…nor obtained a Doctor of Medicine degree…”

As of this morning around 10:00 AM, the meeting agenda has not yet been finalized. So far, it looks like there will be no vote on the Covid-19 vaccine update, although there will be a vote on Thimerosal in flu vaccines about which the FDA has previously published an extensive summary.  

More Mall Walking for Everyone!

I don’t get out often to the mall to do mall walking, but I did today. I put on a little over 2.5 miles on my step counter. Mall walking is OK for exercise although I have to drive over there. Right next door to the entrance to the mall is the outdoor entrance to Planet Fitness, which is kind of ironic. But you have to pay a membership fee to use the facilities there. You can just walk through the mall for free and it opens an hour before the other shops just to accommodate mall walkers.

I think mall walking does wonders for my lower back. I see a lot of older people who look like they make mall walking regular exercise. They’re my age or older. Some of them have physical challenges that may be the reasons why they mall walk, that is, for conditioning. Their physicians might have even recommended it.

A minority of mall walkers I see are young, so this isn’t just for the elderly. Occasionally I’ll see a group who are challenged in various ways. Today it looked like the guy who was blind and using a cane was right out in front, actually leading the group.

Mall walking has advantages over, say, walking downtown. It beats getting clobbered by an exploding manhole lid, bit by a dog, or mugged.

There are some studies about mall walking, but the authors of a 2015 review mainly noted that there’s a need for more rigorous studies. Their conclusion sounds a little grumpy:

“We found the potential for mall walking programs to be implemented in various communities as a health promotion measure. However, the research on mall walking programs is limited and has weak study designs. More rigorous research is needed to define best practices for mall walking programs’ reach, effectiveness, adoption, implementation, and maintenance.”

Farren L, Belza B, Allen P, Brolliar S, Brown DR, Cormier ML, Janicek S, Jones DL, King DK, Marquez DX, Rosenberg DE. Mall Walking Program Environments, Features, and Participants: A Scoping Review. Prev Chronic Dis. 2015 Aug 13;12:E129. doi: 10.5888/pcd12.150027. PMID: 26270743; PMCID: PMC4552141.

Maybe the authors need to go for a walk.

It’s inspiring to see some of the mall walkers out there despite having major disability of one kind or another. I often see a lady who uses a wheeled walker and cannot hold her head up straight. When she sits down for a break, it looks like she’s collapsed. But she just gets up and at it again a few minutes later.

Mall walking may be understudied—but it’s also underestimated as a sign of resilience in anyone young or old.

University of Minnesota CIDRAP Story on CDC ACIP Meeting Next Week

The University of Minnesota Center for Infectious Disease Research and Policy (CIDRAP) posted a news report about the upcoming CDC ACIP meeting next Wednesday. Apparently, so far the new advisory committee draft agenda does not include a vote on the Covid-19 vaccine.

Sit and Rise Exercise Related to Longevity?

I just read a few news articles and saw a couple of videos on something called the sit and rise or sitting rising exercise. It’s not the same as the sit to stand exercise, which is how many times you stand up from a chair without falling down after drinking several beers. The sit and rise exercise is sitting down and then standing back up in a cross-legged position.

Just to let you know, there are dozens of news stories that claim if you can’t do the sit and rise exercise without using one or both hands or a crane to get back up, you’re marked for death within hours. Make sure your last will and testament is notarized.

OK, I also saw a Snopes fact-check story about the sit and rise thing and it’s a myth that the inability to do it predicts mortality within a few years. It does indicate you have problems with mobility and that could be from a number of factors, including previous joint injuries and not having legs. Check a full-length mirror.

Apparently, there was a study done in Brazil in 2012 that got this story going about imminent mortality if you can’t do the sit and rise cross-legged routine. It looks like there have been news stories about it every year or so since then just to scare old people.

I can’t do the sit and rise cross-legged and wondered if there’s some kind of trick to it. There isn’t and the main problem according to experts are weak glutes. And I’m able to stand on one leg for 30 seconds and I can do 3-4 reps of the single sit to stand exercise on both legs. I also have no problem getting up from a chair from a sitting position without pulling myself up using grab bars or having somebody haul me up with a tow chain.

I can’t remember a time when I could even sit cross-legged, although I guess I did when I was in kindergarten. When I took a Mindfulness Based Stress Reduction (MBSR) course, I had to try to sit cross legged to meditate and I was numb in my hips and knees within a couple of minutes. When I got up, I usually fell over, sustained a minor head injury and was rushed to the ER about 1,200 times (“It’s Dr. Amos again; he’s been trying to sit in that lotus position” “OK, put him in the rack.”).

There’s a web page that gives advice on how to fix a problem with not being able to sit in a crossed leg position for longer than a minute. The author provides a short list of exercises without instructions for how to do them:

Child Pose: I imagine this resembles standing pigeon-toed, holding your crotch and dancing around a little about an hour after drinking a half-gallon of Kool-Aid.

Pigeon Pose: This is kind of like the Child Pose only it’s done while pooping on the head of a statue.

Toe Touch: Self-explanatory but apparently you can touch anything with your toe as long as it’s not something recently expelled from a pigeon.

Vajrasana: It involves contacting extraterrestrials who will assist you by inserting various probes in several orifices while you remain very still to allow the tracking device to be correctly installed.

Lung Pose: I’m not sure how this strengthens your glutes but obviously it involves surgery. Check your insurance.

Bridge Pose: This might tone your glutes if you dive off a bridge without a parachute. Make sure your life insurance policy is up-to-date.

That about does it for the sit and rise cross-legged issue. Remember, it’s only when you do it while cross-eyed that all the trouble starts. Glad I could clear that up.

This essay is satirical.