Thoughts on Upcoming CDC ACIP Meeting

Sena and I are talking about the upcoming CDC meeting on February 28th-29th next week. The agenda looks like they’ll be talking about an “additional dose” of the Covid-19 vaccine.

Given the extent of vaccine fatigue going on, I tried to find a layperson-friendly article on the web about vaccine immunity with details about how long it lasts.

There’s review article from 2022 that helps a little bit. The author says that boosting every few months may not be practical as a long-term strategy. It leads to vaccine fatigue in the population. We all know how low the Covid-19 vaccine uptake has been. The author says that boosters should be offered annually or even less often. There is more to immunity than neutralizing antibodies.

The suggestion of some experts is to offer Covid-19 boosters to whoever wants it. I feel like I’m getting mixed and circular messages when I read that my immunity is “waning,” and I need another one. We’ve gotten every Covid-19 shot since the vaccine campaign began. Experts even differ on whether to call Covid-19 a “seasonal” respiratory virus. That would suggest you could get one shot annually during the respiratory virus season-like the flu shot. Obviously, it’s not that simple if the CDC recommends another Covid-19 vaccine this spring.

And the CDC respiratory virus channel snapshot from February 16, 2024 is a little concerning. A couple of days ago there was a news report that schools in Forest City, Iowa would have to move to remote learning because of outbreaks of influenza, strep throat, and even stomach flu. According to the CDC, respiratory virus activity levels are high all over Iowa, which surprised me this late in the season.

CDC ACIP Meeting February 28-29, 2024 to Discuss Covid-19 and Other Vaccines

There are news stories about a pending CDC-ACIP meeting (February 28-29, 2024) which might include information about a CDC recommendation to possibly add a 3rd additional Covid-19 vaccine booster this spring.

The Covid-19 vaccine portion of the meeting is scheduled for February 28, 2024 at 8:30 AM EST. There will be a vote at 1:55 PM EST that day.

Interestingly, also on the agenda is a discussion about the RSV vaccine on February 29, 2024 at 8:30 AM EST. We wonder whether the committee will talk about the current requirement for a shared clinical-decision making discussion with a physician for getting the RSV vaccine.

New Large Covid-19 Vaccine Study Shows Association with Rare Side Effects Which Other Smaller Studies Have Found

I’ve seen a couple of news stories about the CDC supported large study across many countries which essentially shows that Covid-19 vaccines can be associated with rare side effects. The stories might tend to raise anxiety about the vaccines’ overall safety, which has been repeatedly proven in other studies.

The study is published in the journal Vaccine and the conclusions are consistent with smaller studies showing the Covid-19 vaccines safety although they do have rare side effects.

One of the news stories contacted an expert, Dr. Marc Siegel, clinical professor of medicine at NYU Langone Medical Center, who confirmed that.

Unfortunately, there are over 1200 comments (and counting) containing alarmist and misleading information about the vaccines.

CDC May Change the 5 Day Covid-19 Isolation Guidelines

I see many news headlines reporting that the CDC may be planning to drop the 5 day Covid-19 isolation guidelines. For now I’m taking that as a rumor until the CDC website says something official about it.

Word on the street is that we may know more in April.

Bootless II: Dr. Russell Ledet’s Story

Recall that I had been checking to see if the Distinguished Education Lecture given by Dr. Russell Ledet, MD, PhD on January 17, 2024 during the MLK Celebration of Human Rights would be available for the general public. While somebody may be working on that, I managed to find Dr. Ledet’s YouTube, entitled “Bootless II.” I think it’s a great distillation of his major theme.

Trips and Trip-Killers

I just read this JAMA Network article on trip-killers. It’s about using drugs to stop bad trips caused by hallucinogens.

One mentioned was ketamine. When I was working as a consultation psychiatrist, I was called occasionally to evaluate patients in recovery rooms who were delirious from the ketamine that was sometimes used by anesthesiologists.

I found a paper with a list of ketamine’s limitations, which I think is helpful.

Trips and trip-killers can cause problems.

Thoughts on the Distinguished Education Lecture by Dr. Russell Ledet MD PhD

We enjoyed the Dr. Martin Luther King, Jr. Distinguished Education (originally given on January 17, 2023) by Dr. Russell Ledet. He’s definitely a mover and a shaker and this is another recorded presentation that I wish was available for the general public.

His bio is knockdown impressive. And even more interesting to me is that he’s presently in residency toward boarding in adult psychiatry and child psychiatry as well as pediatrics.

That’s right—triple boarding.

His talk was a fascinating oral autobiography from his upbringing in poverty to his military career, to his undergraduate and graduate college career, and his achievement in organizing a very successful nonprofit, The 15 White Coats. This helps get underrepresented minority students into medicine by giving them inspiration and financial support.

His life story by itself is inspiring. It’s also exhausting. The person introducing him wondered aloud if he ever slept!

He began with a well-known quote by Dr. Martin Luther King, Jr:

“It’s all right to tell a man to lift himself by his own bootstraps, but it is a cruel jest to say to a bootless man that he ought to lift himself by his own bootstraps.”

Dr. Ledet’s story of his path from bootlessness to crowning success is compelling. You really have to hear it from him to get a clear idea of how difficult it was. It’s hard to imagine that a star like him once rummaged through dumpsters for food for the family while his mother was on the lookout to make sure he didn’t get caught.

I think a big part of what kept him going was his wife and kids. In fact, his wife, Mallory Alise, insisted that he take the path because of her fear he would die if he continued a dangerous assignment in the military.

A member of the audience who had a career similar to Dr. Ledet asked a question about what more should he do to make sure young people of color would get the kind of opportunities to succeed. Dr. Ledet had a very good answer, but that was not the most interesting part of the interaction. Firstly, the questioner didn’t sound (I know this is going to sound crass) black. He sounded more like someone who had grown up in the Northern United States—like me. But during the course of the conversation, it was clear that he was black. He just didn’t sound like Dr. Ledet. He also mentioned, almost in passing, that some people of color who succeed may develop imposter syndrome.

This sounded strange at first, but I quickly realized that I sometimes had felt like an imposter. This cuts two ways with me. One was the obvious context in which I came out of an impoverished background to finish college and medical school, and had a career as a consultation-liaison psychiatrist at a university medical center where I published and taught for many years. At times I felt like a phony.

The other situation in which imposter syndrome arose was when I went to Huston-Tillotson University (an HBCU formerly called Huston-Tillotson College) in Austin, Texas back in the 1970s. Most of the students were from the region. I had a Northerner’s accent and somebody once remarked on it, asking me “Why do you talk so hard?” I was easily identified simply because of how I spoke. I didn’t always feel comfortable, despite for the first time being not the only black guy in school. Ironically, I didn’t feel like I fit in, even in an HBCU. Even among those who looked like me, I sometimes felt like a phony. But that was not an enduring affliction.

And I think Dr. Ledet has a great deal of confidence and energy. More power to him.

FDA Issues Warning Not to Use Tianeptine

There have been several warnings from the FDA and others for several years (going back to at least 2014) against using tianeptine. It’s used as an antidepressant in other countries, but “FDA is warning consumers not to purchase or use any Neptune’s Fix products, or any other product with tianeptine — a potentially dangerous substance that is not FDA-approved for any medical use but is illegally sold with claims to improve brain function and treat anxiety, depression, pain, opioid use disorder and other conditions.”

Tianeptine has been called other names including Neptune’s Fix, Zaza, Coaxil, Stablon, Tianna Red, and others.

It reportedly has been banned in several states. Southern Iowa Mental Health Center published an educational web page in 2022 indicating that a review between 2000 and 2017 found a sharp untick in tianeptine-related poisoning calls during that time period.

The web page also pointed out that “The study specifically noted that while the drug was implicated in just five poisoning calls back in 2014, that figure rose to 38 in 2015, 83 by 2016, and 81 by 2017. And most of those calls involved relatively young people, between the ages of 21 and 40.”

Old Doctors vs Young Doctors

I ran across a recently published web article that originated from the Wall Street Journal (WSJ), to which I don’t have access because I’m not a subscriber. The title is “Do Younger or Older Doctors Get Better Results?” and it’s in the form of an essay by Pete Ryan.

It’s been picked up by over 130 news outlets and is actually based on an open access study published in the British Medical Journal (BMJ) in 2017, (BMJ 2017;357:j1797): Tsugawa Y, Newhouse J P, Zaslavsky A M, Blumenthal D M, Jena A B. Physician age and outcomes in elderly patients in hospital in the US: observational study BMJ 2017; 357:j1797 doi:10.1136/bmj. j1797.

I had a quick look at the rapid response comments. A couple resonated with me. One was from a retired person:

“I did not see specific patient age statistics vs physician age groupings. Wouldn’t older patients, whose risk of dying soon was higher, want to see their own older doctors? Lots of uncontrolled variables in this study… I also agree with one of the other comments that a patient who knew the end of their life was near would seek care from an older physician that would tend to be more empathetic with a patient of their own age.”

Another was from an emergency room physician, Dr. Cloyd B. Gatrell, who entered the comment on June 8, 2017. Part of it echoed my sentiments exactly:

“The authors’ own statements call their conclusion into question: “Our findings might just as likely reflect cohort effects rather than declining clinical performance associated with greater age….”

I suspect most of the web articles spawned by the study didn’t really talk about the study itself. They probably were mainly about your attitude if the doctor who entered the exam room had gray hair or not.

The study involved internal medicine hospitalists and measured mortality rates comparing physicians were in different age ranges from less than 40 years to over 60.

It got me wondering if you could do a similar study of younger and older psychiatrists. Maybe something like it has been done. I’m not sure what an appropriate outcome measure might be. If you focus on bad outcomes, completed suicides are probably too rare and can involve psychiatrists of any age. The quote that comes to mind:

“There are two kinds of psychiatrists—those who have had a patient die by suicide, and those who will.”

Robert Simon, MD, forensic psychiatrist

I doubt they would fall into any particular age category more often than any other.

Anyway, on the subject of physicians who are getting older and required to retire at a specific age, recent news revealed that Scripps Clinical Medical Group agreed to pay almost $7 million to physicians to settle an age and disability discrimination charge filed with the U.S. Equal Opportunity Commission over a policy requiring them to retire at age 75.

And this reminds me of an article in Hektoen International A Journal of Medical Humanities: Jean Astruc, the “compleat physician.” He was a doctor in the Age of Enlightenment and was a geriatrician. An excerpt from the article:

Jean Astruc had a special interest in geriatrics and in 1762 gave a series of lectures that were taken down by one of his students. He described how in old age the skin becomes thick and hard, the hair and teeth fall out, there becomes need for glasses, respiration becomes labored, urine escapes, there is insomnia, and people forget what they have done during the day but remember every detail of what they have done in the distant past. He recommended diet, some wine to help the circulation, exercise, long sleep, and “a life from bed to table and back to bed.”

I think there is a contradiction in Astruc’s recommendations.

I retired voluntarily a little over 3 years ago. It just so happens that one of the reasons was the Maintenance of Certification (MOC) program, which the BMJ study authors mentioned in the first paragraph of the introduction:

“Interest in how quality of care evolves over a physician’s career has revived in recent years, with debates over how best to structure programs for continuing medical education, including recent controversy in the US regarding maintenance of certification programs.”

That reminds me that I got an email a few days ago from Jeffrey M. Lyness, MD, the new President and CEO of the American Board of Psychiatry and Neurology (ABPN) in January of 2023, replacing Larry Faulkner, MD. It was a letter explaining how I could recertify. I decided not to renew several years ago and I’m not thinking of coming out of retirement. I have always been an opponent of the MOC.

Maybe he sent me the letter because he found the Clinical Chart Review Module on delirium that a resident and I made in 2018. As of January 24, 2024 you can still find the module on the web site just by typing in the word “delirium” in the search field. It could be the only document about delirium on the ABPN web site, although that’s difficult to believe.

On the other hand, it’s one of two modules that are labeled as approved although valid through December 31, 2023. Maybe it’s headed for retirement.